Department of Chemistry & Biochemistry, University of Maryland, College Park, MD 20742, USA.
Nanomedicine (Lond). 2011 Jul;6(5):921-8. doi: 10.2217/nnm.11.75.
Treatment for intoxication involves the neutralization or clearance of a toxic compound, but the current methods of treatment are limited in their ability to safely and effectively detoxify the patient. Emerging research has focused on using nanoparticles as parenteral detoxifying agents to circulate through the body and capture toxins. The variable compositions of these nanoparticles control the mechanism in which they capture and remove specific compounds. As discussed in this article, the recent methods for utilizing nanoparticles for detoxification show great potential for intoxication treatment. However, several challenges must be overcome before a universal nanoparticle detoxification method is available for clinical use.
中毒的治疗包括中和或清除有毒化合物，但目前的治疗方法在安全有效地为患者解毒方面能力有限。新兴的研究集中在使用纳米粒子作为肠外解毒剂，使其在体内循环并捕获毒素。这些纳米粒子的可变组成控制了它们捕获和去除特定化合物的机制。正如本文所讨论的，利用纳米粒子解毒的最新方法为中毒治疗展示了巨大的潜力。然而，在通用的纳米粒子解毒方法可用于临床使用之前，还必须克服一些挑战。
