在做出承诺之前会有压力——即使对于干细胞来说也是如此。
Tension precedes commitment-even for a stem cell.
作者信息
Settleman Jeffrey
机构信息
Massachusetts General Hospital Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.
出版信息
Mol Cell. 2004 Apr 23;14(2):148-50. doi: 10.1016/s1097-2765(04)00207-2.
Abstract
The differentiation potential of stem cells is influenced by cell density. An article in the April issue of Developmental Cell demonstrates that lineage commitment by mesenchymal stem cells is regulated by shape-induced changes in Rho GTPase activity and cytoskeletal tension.
摘要
干细胞的分化潜能受细胞密度影响。《发育细胞》4月刊上的一篇文章表明，间充质干细胞的谱系定向受Rho GTPase活性和细胞骨架张力的形状诱导变化调控。
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