1992年至1994年在马来西亚分离出的四种致脑炎登革热3型病毒株的神经毒性并非归因于其包膜蛋白。
Neurovirulence of four encephalitogenic dengue 3 virus strains isolated in Malaysia (1992-1994) is not attributed to their envelope protein.
作者信息
Fong Mun-Yik, Yusup Roziyah, Yusof Rohana, Lam Sai-Kit
机构信息
Department of Parasitology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
出版信息
Trans R Soc Trop Med Hyg. 2004 Jun;98(6):379-81. doi: 10.1016/j.trstmh.2003.11.004.
PMID:15099995
Abstract
The amino acid sequences of the envelope (E) protein of four encephalitogenic and five non-encephalitogenic dengue 3 virus strains isolated in Malaysia were determined and compared. Multiple sequence alignment revealed a high degree of similarity in the E protein of the strains suggesting that neurovirulence of these four encephalitogenic strains is not attributed to this protein.
摘要
测定并比较了在马来西亚分离出的4株致脑炎型和5株非致脑炎型登革热3型病毒株包膜（E）蛋白的氨基酸序列。多序列比对显示这些病毒株的E蛋白具有高度相似性，这表明这4株致脑炎型病毒株的神经毒力并非归因于该蛋白。
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