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首个二氨基虎皮楠生物碱——虎皮帕西宁，具有来自巴东虎皮楠的前所未有的杂六环骨架。

First diamino Daphniphyllum alkaloid, daphnipaxinin, with an unprecedented heterohexacyclic skeleton from Daphniphyllum paxianum.

作者信息

Yang Sheng-Ping, Yue Jian-Min

机构信息

State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai, 201203, P. R. China.

出版信息

Org Lett. 2004 Apr 29;6(9):1401-4. doi: 10.1021/ol049756j.

DOI:10.1021/ol049756j

PMID:15101752

Abstract

[structure: see text] The first diamino Daphniphyllum alkaloid, daphnipaxinin (1), with an unprecedented hexacyclic fused skeleton, along with a known alkaloid, daphnicyclidin A (2), was isolated from the stem of Daphniphyllum paxianum Rosenth. The structure and absolute stereochemistry of 1 were established by spectral methods, especially two-dimensional NMR techniques and CD analysis.

摘要

[结构：见正文] 从巴山虎皮楠（Daphniphyllum paxianum Rosenth.）的茎中分离得到了首个具有前所未有的六环稠合骨架的二氨基虎皮楠生物碱——虎皮帕西宁（1），以及一种已知生物碱——虎皮环定A（2）。通过光谱方法，特别是二维核磁共振技术和圆二色分析确定了1的结构和绝对立体化学。