刺叶虎皮楠碱D，一种来自大叶虎皮楠的具有前所未有的稠合五环骨架的新型生物碱。

Calyciphylline D, a novel alkaloid with an unprecedented fused-pentacyclic skeleton from Daphniphyllum calycinum.

作者信息

Saito Shizuka, Kubota Takaaki, Fukushi Eri, Kawabata Jun, Zhang Huiping, Kobayashi Jun'ichi

机构信息

Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.

出版信息

Org Lett. 2007 Mar 29;9(7):1207-9. doi: 10.1021/ol0631455. Epub 2007 Mar 6.

DOI:10.1021/ol0631455

PMID:17338533

Abstract

[structure: see text]. Calyciphylline D (1), a novel Daphniphyllum alkaloid with an unprecedented fused-pentacyclic skeleton containing a 8-azatricyclo[4.2.1.0.4,8]nonane ring system, has been isolated from the leaves of Daphniphyllum calycinum (Daphniphyllaceae), and the structure and relative stereochemistry were elucidated on the basis of spectroscopic data.

摘要

[结构：见正文]。从 Calyciphyllum calycinum（虎皮楠科）的叶子中分离出了卡里西菲林 D（1），一种具有前所未有的稠合五环骨架且包含 8-氮杂三环[4.2.1.0.4,8]壬烷环系的新型虎皮楠生物碱，并根据光谱数据阐明了其结构和相对立体化学。