Niznikiewicz Margaret A, Friedman Michelle, Shenton Martha E, Voglmaier Martina, Nestor Paul G, Frumin Melissa, Seidman Larry, Sutton John, McCarley Robert W
Department of Psychiatry, Harvard Medical School, Neuroscience Laboratory, Brockton/West Roxbury VAMC, Brockton, Massachusetts 02301, USA.
Psychophysiology. 2004 May;41(3):367-71. doi: 10.1111/1469-8986.2004.00173.x.
Accumulating evidence suggests that schizophrenic patients do not use context efficiently. Also, studies suggest similarities in clinical and cognitive profiles between schizophrenic and schizotypal personality disorder (SPD) individuals, and epidemiological studies point to a genetic link between the two disorders. This study examined electrophysiological correlates of processing sentence context in a group of SPD women in a classical N400 sentence paradigm. The study assessed if the dysfunction in context use found previously in schizophrenia and male SPD also exists in female SPD. We tested 17 SPD and 16 matched normal control women. The results suggest the presence of abnormality in context use in female SPD similar to that previously reported for male schizophrenic and SPD individuals, but of lesser degree of severity. In SPD women, relative to their comparison group, a more negative N400 was found only to auditory congruent sentences.
越来越多的证据表明，精神分裂症症患者不能有效地利用语境。此外，研究表明精神分裂症患者与分裂型人格障碍（SPD）个体在临床和认知特征上存在相似之处，并且流行病学研究指出这两种障碍之间存在遗传联系。本研究在经典的N400句子范式中，对一组患有SPD的女性处理句子语境的电生理相关性进行了研究。该研究评估了先前在精神分裂症和男性SPD中发现的语境使用功能障碍在女性SPD中是否也存在。我们测试了17名患有SPD的女性和16名匹配的正常对照女性。结果表明，女性SPD在语境使用方面存在异常，类似于先前报道的男性精神分裂症患者和SPD个体，但严重程度较低。在患有SPD的女性中，相对于对照组，仅在听觉一致的句子中发现了更负的N400。
