Niznikiewicz M A, Voglmaier M, Shenton M E, Seidman L J, Dickey C C, Rhoads R, Teh E, McCarley R W
Department of Psychiatry, Harvard Medical School, Boston, MA, USA.
Am J Psychiatry. 1999 Jul;156(7):1052-8. doi: 10.1176/ajp.156.7.1052.
This study examined whether the electrophysiological correlates of language processing found previously to be abnormal in schizophrenia are also abnormal in schizotypal individuals. The authors used the N400 component to evaluate language dysfunction in schizotypal individuals.
Event-related potentials were recorded in 16 comparison subjects and 17 schizotypal individuals (who met full DSM-III-R criteria) to sentences presented both visually and aurally; half of the sentences ended with an expected word completion (congruent condition), and the other half ended with an unexpected word completion (incongruent condition).
In the congruent condition, the N400 amplitude was more negative in individuals with schizotypal personality disorder than in comparison subjects in both the visual and auditory modalities. In addition, in the visual modality, the N400 latency was prolonged in the individuals with schizotypal personality disorder.
The N400 was found to be abnormal in the individuals with schizotypal personality disorder relative to comparison subjects. The abnormality was similar to the abnormality the authors' laboratory reported earlier in schizophrenic subjects, in which the N400 amplitude was found to be more negative in both congruent and incongruent sentence completions. The N400 abnormality is consistent with the inefficient use of context.
本研究调查了先前发现的精神分裂症患者语言加工过程中异常的电生理关联在分裂型人格障碍个体中是否同样异常。作者使用N400成分评估分裂型人格障碍个体的语言功能障碍。
对16名对照受试者和17名符合完整DSM-III-R标准的分裂型人格障碍个体记录事件相关电位，刺激句子通过视觉和听觉两种方式呈现；一半句子以预期的单词完成结尾（一致条件），另一半以意外的单词完成结尾（不一致条件）。
在一致条件下，分裂型人格障碍个体在视觉和听觉两种方式下的N400波幅均比对照受试者更负向。此外，在视觉方式下，分裂型人格障碍个体的N400潜伏期延长。
相对于对照受试者，分裂型人格障碍个体的N400异常。该异常与作者实验室先前报告的精神分裂症患者的异常相似，在精神分裂症患者中，一致和不一致句子完成时的N400波幅均更负向。N400异常与上下文利用效率低下一致。
