结核分枝杆菌双亮氨酸和泛酸盐营养缺陷型在豚鼠中引发的保护作用。
Protection elicited by a double leucine and pantothenate auxotroph of Mycobacterium tuberculosis in guinea pigs.
作者信息
Sampson Samantha L, Dascher Christopher C, Sambandamurthy Vasan K, Russell Robert G, Jacobs William R, Bloom Barry R, Hondalus Mary K
机构信息
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
出版信息
Infect Immun. 2004 May;72(5):3031-7. doi: 10.1128/IAI.72.5.3031-3037.2004.
Abstract
We developed a live, fully attenuated Mycobacterium tuberculosis vaccine candidate strain with two independent attenuating auxotrophic mutations in leucine and pantothenate biosynthesis. The deltaleuD deltapanCD double auxotroph is fully attenuated in the SCID mouse model and highly immunogenic and protective in the extremely sensitive guinea pig tuberculosis model, reducing both bacterial burden and disease pathology.
摘要
我们开发了一种活的、完全减毒的结核分枝杆菌疫苗候选菌株，该菌株在亮氨酸和泛酸生物合成中具有两个独立的减毒营养缺陷型突变。ΔleuD ΔpanCD双营养缺陷型在SCID小鼠模型中完全减毒，在极其敏感的豚鼠结核病模型中具有高度免疫原性和保护性，可降低细菌载量和疾病病理。
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1
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J Exp Med. 1937 Nov 30;66(6):761-88. doi: 10.1084/jem.66.6.761.
2
Immunization with a mycobacterial lipid vaccine improves pulmonary pathology in the guinea pig model of tuberculosis.
Int Immunol. 2003 Aug;15(8):915-25. doi: 10.1093/intimm/dxg091.
3
Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis.
Nat Med. 2003 May;9(5):533-9. doi: 10.1038/nm859. Epub 2003 Apr 14.
4
A DNA prime-live vaccine boost strategy in mice can augment IFN-gamma responses to mycobacterial antigens but does not increase the protective efficacy of two attenuated strains of Mycobacterium bovis against bovine tuberculosis.
Immunology. 2003 Apr;108(4):548-55. doi: 10.1046/j.1365-2567.2003.01589.x.
5
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Infect Immun. 2003 Apr;71(4):2192-8. doi: 10.1128/IAI.71.4.2192-2198.2003.
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