巨细胞病毒DNA聚合酶的自然多态性存在于位于结构域δ-C与II之间以及结构域III与I之间的两个非保守区域。
Natural polymorphism of cytomegalovirus DNA polymerase lies in two nonconserved regions located between domains delta-C and II and between domains III and I.
作者信息
Fillet Anne-Marie, Auray Laetitia, Alain Sophie, Gourlain Karine, Imbert Berthe Marie, Najioullah Fatiha, Champier Gael, Gouarin Stéphanie, Carquin Jocelyne, Houhou Nadhira, Garrigue Isabelle, Ducancelle Alexandra, Thouvenot Danielle, Mazeron Marie-Christine
机构信息
Virology Laboratories, Hospital AP-HP Pitié-Salpêtrière and University Paris VI, Paris, France.
出版信息
Antimicrob Agents Chemother. 2004 May;48(5):1865-8. doi: 10.1128/AAC.48.5.1865-1868.2004.
Abstract
We described the natural polymorphism of cytomegalovirus DNA polymerase in 42 unrelated isolates susceptible to ganciclovir, foscarnet, and cidofovir. All variations, including an eight-amino-acid deletion, were located between domains delta-C and II and between domains III and I, suggesting that these specific residues are not involved in enzymatic functions.
摘要
我们描述了42株对更昔洛韦、膦甲酸和西多福韦敏感的无关巨细胞病毒DNA聚合酶的自然多态性。所有变异，包括一个八氨基酸缺失，均位于结构域δ-C与II之间以及结构域III与I之间，这表明这些特定残基不参与酶促功能。
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