近距离放射疗法治疗IV期舌根癌
Brachytherapy in the treatment of Stage IV carcinoma of the base of tongue.
作者信息
Cano Elmer R, Johnson Jonas T, Carrau Ricardo, Agarwala Sanjiv, Flickinger John, Quader Mubina
机构信息
Department of Radiation Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.
出版信息
Brachytherapy. 2004;3(1):41-8. doi: 10.1016/j.brachy.2004.02.001.
PURPOSE
Survival in patients with Stage IV carcinoma of the base of tongue (BOT) treated by surgery and radiotherapy remains poor. External beam radiotherapy (EBRT) and brachytherapy (BT) have been used as an alternative treatment.
METHODS AND MATERIALS
Eighteen patients with Stage IV carcinoma of the BOT were treated by EBRT and BT.
RESULTS
Local control is 89%. The 5-year overall (OS) and disease specific survival (DSS) rates are 52% and 67%. No neck node positive patient implanted in the neck developed cervical metastases. Two patients (11%) developed complications.
CONCLUSIONS
Local regional control, survival, and complications in patients with Stage IV carcinoma of the BOT treated by EBRT and BT have been satisfactory. The use of brachytherapy for nodal metastases has eliminated the need for neck dissection. We recommend this approach in the treatment of Stage IV carcinoma of the BOT.
目的
接受手术和放疗的IV期舌根癌患者的生存率仍然很低。外照射放疗（EBRT）和近距离放疗（BT）已被用作替代治疗方法。
方法和材料
18例IV期舌根癌患者接受了EBRT和BT治疗。
结果
局部控制率为89%。5年总生存率（OS）和疾病特异性生存率（DSS）分别为52%和67%。颈部植入的无颈部淋巴结阳性患者未发生颈部转移。2例患者（11%）出现并发症。
结论
EBRT和BT治疗的IV期舌根癌患者的局部区域控制、生存率和并发症情况令人满意。使用近距离放疗治疗淋巴结转移消除了颈部清扫的必要性。我们推荐这种方法用于IV期舌根癌的治疗。
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