地塞米松和右旋糖酐40治疗32例重症急性胰腺炎患者。
Dexamethasone and dextran 40 treatment of 32 patients with severe acute pancreatitis.
作者信息
Wang Zi-Fa, Liu Chang, Lu Yi, Dong Rui, Xu Jun, Yu Liang, Yao Ying-Min, Liu Qing-Guang, Pan Cheng-En
机构信息
Department of Surgery, First Hospital, Xi'an Jiaotong University, Shaanxi Province, China.
出版信息
World J Gastroenterol. 2004 May 1;10(9):1333-6. doi: 10.3748/wjg.v10.i9.1333.
AIM
Based on the pathogenesis of severe acute pancreatitis and our experimental studies, to investigate the effect of dexamethasone and dextran in treatment of patients with severe acute pancreatitis.
METHODS
Thirty-two patients with severe acute pancreatitis were treated with 0.5-1 mg/kg per day dexamethasone for 3-5 d, and 500-1,000 mL/d of dextran 40 for 7 d, besides the routine therapy.
RESULTS
After 4-8 h of treatment, abdominal pain began to be relieved; range of tenderness began to be localized in 27 patients. They were cured with nonsurgical treatment. Five of them were deteriorated, and treated with surgery. Four patients in this group died.
CONCLUSION
Dexamethasone and dextran 40 block the pathologic process of severe acute pancreatitis through inhibition of inflammatory mediators and improvement of microcirculation disorders respectively.
目的
基于重症急性胰腺炎的发病机制及我们的实验研究，探讨地塞米松和右旋糖酐对重症急性胰腺炎患者的治疗作用。
方法
32例重症急性胰腺炎患者，除常规治疗外，给予地塞米松0.5 - 1mg/（kg·d），连用3 - 5天，右旋糖酐40 500 - 1000ml/d，连用7天。
结果
治疗4 - 8小时后，腹痛开始缓解；27例患者压痛范围开始局限，经非手术治疗治愈。其中5例病情恶化，行手术治疗。该组4例患者死亡。
结论
地塞米松和右旋糖酐40分别通过抑制炎症介质和改善微循环障碍阻断重症急性胰腺炎的病理过程。
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