信号淋巴细胞激活分子家族受体在有和没有与SAP相关的衔接蛋白的情况下调节免疫。
SLAM Family Receptors Regulate Immunity with and without SAP-related Adaptors.
作者信息
Veillette André
机构信息
Laboratory of Molecular Oncology, Clinical Research Institute on Montreal, Québec, Canada.
出版信息
J Exp Med. 2004 May 3;199(9):1175-8. doi: 10.1084/jem.20040588.
Abstract
Two papers describing mice deficient in signaling lymphocyte activation molecule and 2B4 represent the first accounts of immune phenotypes in animals lacking members of the SLAM family of receptors. The findings provide definitive evidence of the importance of SLAM-related receptors in the regulation of T cell, macrophage, and natural killer cell functions.
摘要
两篇描述缺乏信号淋巴细胞激活分子和2B4的小鼠的论文，首次阐述了缺乏信号淋巴细胞激活分子相关受体家族成员的动物的免疫表型。这些发现为信号淋巴细胞激活分子相关受体在调节T细胞、巨噬细胞和自然杀伤细胞功能中的重要性提供了确凿证据。
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