Ostrakhovitch Elena A, Li Shawn S-C
Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, Canada.
Biochem Cell Biol. 2006 Dec;84(6):832-43. doi: 10.1139/o06-191.
The signaling lymphocyte-activating molecule (SLAM) family immunoreceptors are expressed in a wide array of immune cells, including both T and B lymphocytes. By virtue of their ability to transduce tyrosine phosphorylation signals through the so-called ITSM (immunoreceptor tyrosine-based switch motif) sequences, they play an important part in regulating both innate and adaptive immune responses. The critical role of the SLAM immunoreceptors in mediating normal immune reactions was highlighted in recent findings that SAP, a SLAM-associated protein, modulates the activities of various immune cells through interactions with different members of the SLAM family expressed in these cells. Importantly, mutations or deletions of the sap gene in humans result in the X-linked lymphoproliferative syndrome. In this review, we summarize current knowledge and survey the latest developments in signal transduction events triggered by the activation of SLAM family receptors in different cell types.
信号淋巴细胞激活分子（SLAM）家族免疫受体在多种免疫细胞中表达，包括T淋巴细胞和B淋巴细胞。凭借其通过所谓的免疫受体酪氨酸基开关基序（ITSM）序列转导酪氨酸磷酸化信号的能力，它们在调节先天性和适应性免疫反应中发挥重要作用。SLAM免疫受体在介导正常免疫反应中的关键作用在最近的研究结果中得到了强调，即SAP（一种与SLAM相关的蛋白）通过与这些细胞中表达的SLAM家族不同成员相互作用来调节各种免疫细胞的活性。重要的是，人类sap基因的突变或缺失会导致X连锁淋巴增殖综合征。在这篇综述中，我们总结了当前的知识，并审视了不同细胞类型中SLAM家族受体激活引发的信号转导事件的最新进展。
