OSW-1的全合成。
A total synthesis of OSW-1.
作者信息
Xue Jie, Liu Peng, Pan Yanbin, Guo Zhongwu
机构信息
Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, USA.
出版信息
J Org Chem. 2008 Jan 4;73(1):157-61. doi: 10.1021/jo7018812. Epub 2007 Dec 8.
Abstract
A new and practical method was developed to synthesize OSW-1, a natural saponin with potent antitumor activities, from (+)-dehydroisoandrosterone, l-arabinose, and D-xylose on gram scale. The synthesis was achieved in 10 linear steps with an overall yield of 6.4% starting from (+)-dehydroisoandrosterone.
摘要
开发了一种新的实用方法，以克级规模从（+）-脱氢异雄甾酮、L-阿拉伯糖和D-木糖合成具有强大抗肿瘤活性的天然皂苷OSW-1。从（+）-脱氢异雄甾酮开始，该合成以10个线性步骤完成，总收率为6.4%。
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