Young Genevieve S, Maharaj Nicole J, Conquer Julie A
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada.
Lipids. 2004 Feb;39(2):117-23. doi: 10.1007/s11745-004-1209-3.
Several psychiatric disorders, including juvenile Attention Deficit/Hyperactivity Disorder (ADHD), have been associated with abnormalities of certain long-chain PUFA (LCPUFA). Despite this reported association, the FA levels of patients with the adult form of ADHD have not previously been evaluated. In this study we measured the total blood phospholipid FA concentrations in 35 control subjects and 37 adults with ADHD symptoms to determine whether adults with ADHD symptoms would show abnormalities of FA relative to control subjects. In the serum phospholipids, adults with ADHD symptoms had significantly lower levels of total saturated, total polyunsaturated, and total omega-6 (n-6) FA, as well as the omega-3 (n-3) LCPUFA DHA (22:6n-3), and significantly higher levels of total monounsaturated FA and the n-3 LCPUFA docosapentaenoic acid (22:5n-3). In the erythrocyte membrane phospholipids, adults with ADHD symptoms had significantly lower levels of total PUFA, total n-3 FA, and DHA, and significantly higher levels of total saturated FA. Neither serum nor erythrocyte membrane phospholipid DHA was related to ADHD symptom severity (as assessed by the Amen questionnaire) in ADHD subjects. Although the exact cause of these variations is unknown, both environmental and genetic factors may be involved.
包括青少年注意力缺陷多动障碍（ADHD）在内的几种精神疾病，都与某些长链多不饱和脂肪酸（LCPUFA）异常有关。尽管有这种报道的关联，但之前尚未评估成人形式ADHD患者的脂肪酸水平。在本研究中，我们测量了35名对照受试者和37名有ADHD症状的成年人的全血磷脂脂肪酸浓度，以确定有ADHD症状的成年人相对于对照受试者是否会出现脂肪酸异常。在血清磷脂中，有ADHD症状的成年人的总饱和脂肪酸、总多不饱和脂肪酸、总ω-6（n-6）脂肪酸以及ω-3（n-3）长链多不饱和脂肪酸DHA（22:6n-3）水平显著较低，而总单不饱和脂肪酸和n-3长链多不饱和脂肪酸二十二碳五烯酸（22:5n-3）水平显著较高。在红细胞膜磷脂中，有ADHD症状的成年人的总多不饱和脂肪酸、总n-3脂肪酸和DHA水平显著较低，而总饱和脂肪酸水平显著较高。在ADHD受试者中，血清和红细胞膜磷脂DHA均与ADHD症状严重程度（通过阿门问卷评估）无关。尽管这些变化的确切原因尚不清楚，但环境和遗传因素可能都有涉及。
