吸烟对体外单采制品中血小板功能的影响。
Impact of tobacco smoking on platelet function in apheresis products in vitro.
作者信息
Scheinichen D, Heuft H-G, Renken C, Jüttner B, Jaeger K, Schürholz T, Blasczyk R, Piepenbrock S, Elsner H-A
机构信息
Department of Anaesthesiology, Hannover Medical School, Hannover, Germany.
出版信息
Vox Sang. 2004 May;86(4):252-6. doi: 10.1111/j.0042-9007.2004.00507.x.
BACKGROUND AND OBJECTIVES
The aim of this study was to analyse the platelet function, over a 5-day time-period, of apheresis-derived platelet concentrates obtained from smokers and non-smokers.
MATERIALS AND METHODS
Smoker and non-smoker plateletpheresis products were investigated on days 1, 3 and 5 of storage. Receptor expression (as evaluated by flow cytometry) and the platelet aggregation response were measured.
RESULTS
There was only a slight loss of platelet function in apheresis products from smokers compared to non-smokers.
CONCLUSIONS
Smoking does not significantly change the quality of platelet preparations. The current practice, of not to exclude smokers from platelet donation, can be continued.
背景与目的
本研究旨在分析在5天时间内，从吸烟者和非吸烟者采集的单采血小板浓缩物的血小板功能。
材料与方法
在储存的第1天、第3天和第5天对吸烟者和非吸烟者的单采血小板制品进行研究。检测受体表达（通过流式细胞术评估）和血小板聚集反应。
结果
与非吸烟者相比，吸烟者的单采制品中血小板功能仅有轻微丧失。
结论
吸烟不会显著改变血小板制剂的质量。目前不将吸烟者排除在血小板捐献之外的做法可以继续。
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