在接触α-淀粉酶的队列中，工作相关呼吸道症状与致敏作用的暴露-反应关系。
Exposure-response relations for work related respiratory symptoms and sensitisation in a cohort exposed to alpha-amylase.
作者信息
Brisman J, Nieuwenhuijsen M J, Venables K M, Putcha V, Gordon S, Taylor A J N
机构信息
Department of Occupational and Environmental Medicine, Imperial College (NHLI), London SW3 6LR, UK.
出版信息
Occup Environ Med. 2004 Jun;61(6):551-3. doi: 10.1136/oem.2002.006395.
AIMS
To explore relations between exposure to fungal alpha-amylase and the risk of new work related respiratory symptoms or sensitisation.
METHODS
A prospective cohort study among 300 bakers and millers was followed up for a maximum of seven years. Exposure to alpha-amylase was estimated by air measurements and questionnaires and classified into three categories. Symptoms were recorded with a self-administered questionnaire and skin sensitisation assessed using skin prick test (SPT).
RESULTS
There were 36 new cases of chest symptoms, 86 of eyes/nose symptoms, and 24 of a positive SPT to alpha-amylase. There were exposure-response relations for chest and eyes/nose symptoms and for sensitisation, and a significantly increased prevalence ratio for chest symptoms in the highest exposure category.
CONCLUSION
A reduction in alpha-amylase exposure is likely to reduce the risk for respiratory morbidity in bakery workers.
目的
探讨接触真菌α淀粉酶与新发工作相关呼吸道症状或致敏风险之间的关系。
方法
对300名面包师和磨坊工人进行了一项前瞻性队列研究，随访时间最长为7年。通过空气测量和问卷调查评估α淀粉酶的接触情况，并将其分为三类。使用自行填写的问卷记录症状，并通过皮肤点刺试验（SPT）评估皮肤致敏情况。
结果
有36例新发胸部症状病例、86例眼/鼻症状病例以及24例对α淀粉酶皮肤点刺试验呈阳性的病例。胸部和眼/鼻症状以及致敏存在接触反应关系，且在最高接触类别中胸部症状的患病率显著增加。
结论
降低α淀粉酶接触水平可能会降低面包店工人呼吸道发病的风险。
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