Koh W-P, Yuan J-M, van den Berg D, Lee H-P, Yu M C
Department of Community, Occupational and Family Medicine, National University of Singapore, MD3, 16 Medical Drive, Singapore 117597, Singapore.
Br J Cancer. 2004 May 4;90(9):1760-4. doi: 10.1038/sj.bjc.6601797.
This case-control study of 310 colorectal cancer cases and 1177 controls in a nested prospective, population-based cohort of Singapore Chinese subjects found a statistically significant association between the cyclooxygenase (COX)-2 -765G>C gene polymorphism and colon cancer risk among high consumers of dietary n-6 polyunsaturated fatty acids (odds ratio=2.38, 95% confidence interval=1.23-4.59).
这项病例对照研究以新加坡华裔人群为基础,在一个嵌套的前瞻性队列中纳入了310例结直肠癌病例和1177名对照。研究发现,对于膳食n-6多不饱和脂肪酸高摄入量人群,环氧合酶(COX)-2 -765G>C基因多态性与结肠癌风险之间存在统计学显著关联(比值比=2.38,95%置信区间=1.23 - 4.59)。