Woutersen R A, Appel M J, van Garderen-Hoetmer A, Wijnands M V
Department of General Toxicology, TNO Nutrition and Food Research Institute, PO Box 360, Zeist 3700 AJ, Netherlands.
Mutat Res. 1999 Jul 15;443(1-2):111-27. doi: 10.1016/s1383-5742(99)00014-9.
Epidemiologic investigations have suggested a relationship between dietary fat intake and various types of cancer incidences. Furthermore, epidemiologic studies as well as studies with animal models have demonstrated that not only the amount but also the type of fat consumed is important. At present, the mechanism by which dietary fat modulates carcinogenesis has not been elucidated. The effects of dietary fat on the development of tumours have been summarized in the present review with emphasis on colorectal, pancreas, breast and prostate cancer. It is concluded that influence on synthesis of prostaglandins and leukotrienes may be the universal mechanism by which dietary fats modulate carcinogenesis.
流行病学调查表明，膳食脂肪摄入量与各类癌症发病率之间存在关联。此外，流行病学研究以及动物模型研究均已证明，摄入脂肪的量固然重要，但其类型同样关键。目前，膳食脂肪调节致癌作用的机制尚未阐明。本综述总结了膳食脂肪对肿瘤发生发展的影响，重点关注结直肠癌、胰腺癌、乳腺癌和前列腺癌。得出的结论是，对前列腺素和白三烯合成的影响可能是膳食脂肪调节致癌作用的普遍机制。
