Zhang Pengjun, Wen Xinyu, Gu Feng, Zhang Xinsheng, Li Juan, Liu Yulan, Dong Jin, Deng Xinxin, Zhu Xu, Tian Yaping
Core Laboratory of Translational Medicine, Chinese PLA General Hospital Beijing, China ; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Interventional Therapy Department, Peking University Cancer Hospital&Institute Beijing, China.
Department of Clinical Biochemistry, State Key Laboratory of Kidney Disease, Chinese PLA General Hospital Beijing, China.
Int J Clin Exp Med. 2015 Sep 15;8(9):15900-9. eCollection 2015.
We aimed to investigate the role of serum levels of polyunsaturated fatty acid (PUFA) in the development of colorectal cancer (CRC). Serum levels of n-3 and n-6 PUFA in 69 healthy control (Ctrl), 62 benign colorectal polys (CRP) and 100 CRC patients were detected by gas chromatograph. The adjusted odds ratio (OR) by quartiles of n-3 and n-6 PUFA were analyzed. During the process of Ctrl to CRP, total n-3 PUFA (OR=0.159, P<0.001), total n-6 PUFA (OR=0.190, P<0.001), C20:5 n-3 (OR=0.263, P=0.030), C22:6 n-3 (OR=0.125, P<0.001), and C18:2 n-6 (OR=0.299, P=0.025) were inversely associated with CRP risk. The ratio of total n-6 PUFA and total n-3 PUFA (OR=4.667, P=0.002), and the ratio of C20:4 n-6 and (C20:5 n-3+C22:6 n-3) (OR=6.000, P<0.001) were positively associated with CRP risk. During the process of CRP to CRC, total n-3 PUFA (OR=4.059, P=0.007), total n-6 PUFA (OR=8.146, P<0.001), C22:6 n-3 (OR=3.789, P=0.048), and C18:2 n-6 (OR=3.667, P=0.045) were positively associated with CRC risk. The ratio of C20:4 n-6 and (C20:5 n-3+C22:6 n-3) (OR=0.588, P=0.001) was inversely associated with CRC. In conclusion, our results found that the total n-3 PUFA, C22:6 n-3, the total n-6 PUFA, C18:2 n-6, and the ratio of C20:4 n-6 and (C20:5 n-3 +C22:6 n-3) played controversy role in the process of CRP and the process of CRC, and may provide nutritional intervention suggestions for the clinical practice.
我们旨在研究血清多不饱和脂肪酸（PUFA）水平在结直肠癌（CRC）发生发展中的作用。采用气相色谱法检测69例健康对照者（Ctrl）、62例大肠良性息肉（CRP）患者和100例CRC患者的血清n-3和n-6多不饱和脂肪酸水平。分析n-3和n-6多不饱和脂肪酸四分位数的校正比值比（OR）。在从Ctrl到CRP的过程中，总n-3多不饱和脂肪酸（OR=0.159，P<0.001）、总n-6多不饱和脂肪酸（OR=0.190，P<0.001）、C20:5 n-3（OR=0.263，P=0.030）、C22:6 n-3（OR=0.125，P<0.001）和C18:2 n-6（OR=0.299，P=0.025）与CRP风险呈负相关。总n-6多不饱和脂肪酸与总n-3多不饱和脂肪酸的比值（OR=4.667，P=0.002）以及C20:4 n-6与（C20:5 n-3+C22:6 n-3）的比值（OR=6.000，P<0.001）与CRP风险呈正相关。在从CRP到CRC的过程中，总n-3多不饱和脂肪酸（OR=4.059，P=0.007）、总n-6多不饱和脂肪酸（OR=8.146，P<0.001）、C22:6 n-3（OR=3.789，P=0.048）和C18:2 n-6（OR=3.667，P=0.045）与CRC风险呈正相关。C20:4 n-6与（C20:5 n-3+C22:6 n-3）的比值（OR=0.588，P=0.001）与CRC呈负相关。总之,我们的研究结果发现,总n-3多不饱和脂肪酸、C22:6 n-３、总n-6多不饱和脂肪酸、C18:2 n-6以及C20:4 n-6与（C20:5 n-3 +C22:6 n-3）的比值在CRP过程和CRC过程中发挥了相互矛盾的作用,并可能为临床实践提供营养干预建议。
