脱羰策略合成氨基酸衍生的烯酰胺：mersacidin 中（Z）-氨基乙烯基-D-半胱氨酸单元的立体选择性合成。
Decarbonylative approach to the synthesis of enamides from amino acids: stereoselective synthesis of the (Z)-aminovinyl-D-cysteine unit of mersacidin.
机构信息
Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47505, USA.
出版信息
Org Lett. 2012 Feb 17;14(4):1030-3. doi: 10.1021/ol203399x. Epub 2012 Feb 1.
Abstract
The Pd- and Ni-promoted decarbonylation of amino acid thioesters proceeds smoothly to yield enamides. The synthesis of the (S)-(Z)-AviMeCys subunit of mersacidin, an MRSA-active lantibiotic, via this approach, is described.
摘要
钯和镍促进的氨基酸硫酯的脱羰反应顺利进行，生成烯酰胺。通过这种方法合成了抗耐甲氧西林金黄色葡萄球菌（MRSA）活性的类脂肽 mersacidin 的（S）-（Z）-AviMeCys 亚基。
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