Jarrett M E D, Varma J S, Duthie G S, Nicholls R J, Kamm M A
Department of Physiology, St Mark's Hospital, Watford Road, Harrow HA1 3UJ, UK.
Br J Surg. 2004 Jun;91(6):755-61. doi: 10.1002/bjs.4545.
Sacral nerve stimulation (SNS) is an effective therapy for faecal incontinence. Published studies derive largely from single centres and there is a need to determine the broader applicability of this procedure.
Prospective data were collected for all patients undergoing SNS in the UK. Records were reviewed to determine the outcome of treatment.
In three UK centres 59 patients underwent peripheral nerve evaluation, with 46 (78 per cent) proceeding to permanent implantation. Of these 46 patients (40 women) all but two had improved continence at a median of 12 (range 1-72) months. Faecal incontinence improved from a median (range) of 7.5 (1-78) to 1 (0-39) episodes per week (P < 0.001). Urgency improved in all but five of 39 patients in whom ability to defer defaecation was determined, improving from a median of 1 (range 0-5) to 10 (range from 1 to more than 15) min (P < 0.001). Maximum anal squeeze pressure and sensory function to rectal distension changed significantly. Significant improvement occurred in general health (P = 0.024), mental health (P = 0.008), emotional role (P = 0.034), social function (P = 0.013) and vitality (P = 0.009) subscales of the Short Form 36 health survey questionnaire. There were no major complications. One implant was removed.
SNS is a safe and effective treatment, in the medium to long term, for faecal incontinence when conservative treatment has failed.
骶神经刺激(SNS)是治疗大便失禁的一种有效疗法。已发表的研究大多来自单一中心,因此有必要确定该手术更广泛的适用性。
收集了英国所有接受SNS治疗患者的前瞻性数据。对记录进行审查以确定治疗结果。
在英国的三个中心,59例患者接受了周围神经评估,其中46例(78%)进行了永久性植入。在这46例患者(40名女性)中,除2例之外,所有患者在中位时间12个月(范围1 - 72个月)时大便失禁情况均有改善。大便失禁次数从中位值(范围)每周7.5次(1 - 78次)改善至1次(0 - 39次)(P < 0.001)。在39例被评估延迟排便能力的患者中,除5例之外,其余患者的便急情况均有改善,从中位值1分钟(范围0 - 5分钟)改善至10分钟(范围1至超过15分钟)(P < 0.001)。最大肛门收缩压和直肠扩张感觉功能有显著变化。简短健康调查问卷36项健康调查的总体健康(P = 0.024)、心理健康(P = 0.008)、情感角色(P = 0.034)、社会功能(P = 0.013)和活力(P = 0.009)子量表有显著改善。无重大并发症。移除了1个植入装置。
当中保守治疗失败时,骶神经刺激在中长期是治疗大便失禁的一种安全有效的方法。