Ceccaldi P-F, Carré-Pigeon F, Youinou Y, Delépine B, Bryckaert P-E, Harika G, Quéreux C, Gaillard D
Service de Gynécologie Obstétrique, Institut Alix de Champagne, Reims, France.
J Gynecol Obstet Biol Reprod (Paris). 2004 May;33(3):192-4. doi: 10.1016/s0368-2315(04)96439-3.
Primary ciliary dyskinesia is a rare etiology of sterility in man (prevalence between 1/6000 and 1/40000). Kartagener's syndrome is an autosomal recessive disorder, characterized by total or partial dysfunction of the ciliary or flagellated cells. This syndrome associates situs inversus, sinusitis, bronchiectasis and occasionally sterility in males. We report a case of immotile cilia syndrome with male infertility and compare the data with four other couples reported in the literature (two couples in Germany, two in the United States). The difficulty is to select an alive sperm cell for ICSI.
原发性纤毛运动障碍是人类不育的一种罕见病因(患病率在1/6000至1/40000之间)。卡塔格内综合征是一种常染色体隐性疾病,其特征为纤毛或鞭毛细胞完全或部分功能障碍。该综合征伴有内脏转位、鼻窦炎、支气管扩张,男性偶尔会出现不育。我们报告一例患有男性不育的不动纤毛综合征病例,并将数据与文献中报道的其他四对夫妇(两对德国夫妇,两对美国夫妇)进行比较。困难在于为卵胞浆内单精子注射选择一个活的精子细胞。