[来自兴安过路黄的两种新三萜皂苷]

[Two new triterpenoid saponins from Lysimachia davurica].

作者信息

Tian Jing-kui, Zou Zhong-mei, Xu Li-zhen, Zhang Hong-wu, Mu Hong-mei, Yang Shi-lin

机构信息

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China.

出版信息

Yao Xue Xue Bao. 2004 Mar;39(3):194-7.

PMID:15171654

Abstract

AIM

To study the triterpenoid saponins in the whole plant of Lysimachia davurica Ledeb.

METHODS

Column chromatography (including AB-8 macroporous resin, silica gel and ODS) was used to separate triterpenoid saponins whose structures were elucidated by ESI-MS, NMR (1D and 2D) and hydrolysis methods.

RESULTS

Two new triterpenoid saponins were isolated and established as 3beta, 16alpha, 28-trihydroxy-olean-12-en-3-0-(beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucuronopyranosyl)-28-0-beta-D-glucopyranoside) (I), 3beta, 16alpha, 28-trihydroxy-olean-12-en-3-O-(beta-D-glucopyranosyl-(1 --> 2)-beta-D-glucuronopyranosyl)-28-0-beta-D-glucopyranoside) (II).

CONCLUSION

Compounds I and II are new compounds and named as davuricosides D and J.

摘要

目的

研究兴安过路黄全草中的三萜皂苷。

方法

采用柱色谱法（包括AB-8大孔树脂、硅胶和ODS）分离三萜皂苷，通过电喷雾电离质谱（ESI-MS）、核磁共振（一维和二维）及水解方法阐明其结构。

结果

分离得到两个新的三萜皂苷，分别鉴定为3β,16α,28-三羟基-齐墩果-12-烯-3-O-(β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃葡萄糖醛酸基)-28-O-β-D-吡喃葡萄糖苷（I）、3β,16α,28-三羟基-齐墩果-12-烯-3-O-(β-D-吡喃葡萄糖基-(1→2)-β-D-吡喃葡萄糖醛酸基)-28-O-β-D-吡喃葡萄糖苷（II）。