[从细梗香草中分离得到的两种新三萜皂苷]

[Two new triterpenoid saponins from Lysimachia capillipes Hemsl].

作者信息

Tian Jing-kui, Zou Zhong-mei, Xu Li-zhen, Xu Li, Zhang Hong-wu, Mu Hong-mei, Xie Chen, Yang Shi-lin

机构信息

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China.

出版信息

Yao Xue Xue Bao. 2004 Sep;39(9):722-5.

PMID:15606022

Abstract

AIM

To study the triterpenoid saponins in the whole plants of Lysimachia capillipes Hemsl..

METHODS

Column chromatography (including AB-8 macroporous resin, silica gel and ODS) was used to separate triterpenoid saponins whose structures were elucidated by ESI-MS, NMR (1D and 2D) and hydrolysis methods.

RESULTS

Two new triterpenoid saponins were isolated and established as 3beta, 22alpha-dihydroxy-16alpha-angeloyloxy-28-->13-lactone-oleanane-3-O-[beta-D-glucopyranosyl-(1-->2)-alpha-L-arabinpyranosyl]-22-O-(6-acetyl)-beta-D-glucopyranoside (I), 3beta, 13beta, 22alpha-trihydroxy-16alpha-acetyloxyoleanane-28-oic acid Na-3-O-[beta-D-glucopyranosyl-(1-->2)-alpha-L-arabinpyranosyl]-22-O-beta-D-glucopyranoside (II).

CONCLUSION

Compounds I and II are new compounds and named as capilliposide I and capilliposide J.

摘要

目的

研究细梗香草全草中的三萜皂苷。

方法

采用柱色谱法（包括AB-8大孔树脂、硅胶和ODS）分离三萜皂苷，通过电喷雾电离质谱（ESI-MS）、核磁共振（1D和2D）及水解方法对其结构进行解析。

结果

分离得到两个新的三萜皂苷，分别鉴定为3β,22α-二羟基-16α-当归酰氧基-28→13-内酯-齐墩果烷-3-O-[β-D-吡喃葡萄糖基-(1→2)-α-L-阿拉伯吡喃糖基]-22-O-(6-乙酰基)-β-D-吡喃葡萄糖苷（I）、3β,13β,22α-三羟基-16α-乙酰氧基齐墩果烷-28-酸Na-3-O-[β-D-吡喃葡萄糖基-(1→2)-α-L-阿拉伯吡喃糖基]-22-O-β-D-吡喃葡萄糖苷（II）。