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无烟烟草制品的尼古丁递送能力及其对南非烟草依赖控制的影响。

Nicotine delivery capabilities of smokeless tobacco products and implications for control of tobacco dependence in South Africa.

作者信息

Ayo-Yusuf O A, Swart T J P, Pickworth W B

机构信息

Department of Community Dentistry, University of Pretoria, South Africa.

出版信息

Tob Control. 2004 Jun;13(2):186-9. doi: 10.1136/tc.2003.006601.

Abstract

OBJECTIVES

Smokeless tobacco (SLT) use is popular among black South African women and children. The study sought to determine the nicotine delivery capability of popular industrialised and traditional SLT brands in South Africa, and to provide information for policy action by regulatory authorities.

DESIGN

Laboratory chemical analysis of four industrialised and one traditional SLT products commercially available, using previously published analytical methods. Potential for dependence was inferred from nicotine delivery capabilities determined by the percentage free base nicotine.

MEASUREMENTS

Moisture, pH, total nicotine, and percentage free base nicotine.

RESULTS

Total nicotine content was between 6-16 mg/g. The pH varied between 7-10 and this correlated with percentage free base nicotine, which ranged between 10-99%. The nicotine delivery capability of the traditional product was lower than that of the industrialised products except for the recently introduced portion bag snus, which had comparable total nicotine but the lowest pH and percentage free base nicotine. The most popular SLT brands showed the highest percentage free base nicotine ever reported for any industrialised SLT or cigarette brands. Small cans contained higher nicotine than the large cans of the same brand tested. Findings from the study support a potential for limited "product graduation" by users.

CONCLUSIONS

South African SLT users are mostly exposed to potentially very highly addictive levels of nicotine that may favour tobacco dependence and its consequent health risks. The increasing use of SLT by women of childbearing age support the need for intensified policy action to control its use.

摘要

目的

无烟烟草(SLT)在南非黑人妇女和儿童中很受欢迎。该研究旨在确定南非流行的工业化和传统SLT品牌的尼古丁释放能力,并为监管当局的政策行动提供信息。

设计

使用先前发表的分析方法,对四种工业化和一种传统SLT商业产品进行实验室化学分析。根据游离碱尼古丁百分比确定的尼古丁释放能力推断出成瘾潜力。

测量

水分、pH值、总尼古丁和游离碱尼古丁百分比。

结果

总尼古丁含量在6 - 16毫克/克之间。pH值在7 - 10之间变化,这与游离碱尼古丁百分比相关,游离碱尼古丁百分比在10 - 99%之间。除了最近推出的部分袋装口含烟,其总尼古丁含量相当,但pH值和游离碱尼古丁百分比最低外,传统产品的尼古丁释放能力低于工业化产品。最受欢迎的SLT品牌显示出任何工业化SLT或香烟品牌中报道的最高游离碱尼古丁百分比。同一品牌的小罐所含尼古丁比大罐高。该研究结果支持用户存在有限的“产品升级”可能性。

结论

南非SLT使用者大多接触到潜在的高成瘾性尼古丁水平,这可能会助长烟草依赖及其随之而来的健康风险。育龄妇女对SLT的使用增加,支持加强政策行动以控制其使用的必要性。

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本文引用的文献

2
Adverse pregnancy outcomes in snuff users.
Am J Obstet Gynecol. 2003 Oct;189(4):939-43. doi: 10.1067/s0002-9378(03)00661-6.
4
Smokeless tobacco and cigarette use among black secondary school students in South Africa.
Subst Use Misuse. 2003 Jun;38(7):1003-16. doi: 10.1081/ja-120017621.
6
Tobacco use in South Africans during 1998: the first demographic and health survey.
J Cardiovasc Risk. 2002 Jun;9(3):161-70. doi: 10.1177/174182670200900305.
8
Smokeless tobacco use and cancer of the upper respiratory tract.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 May;93(5):511-5. doi: 10.1067/moe.2002.123497.
9
Slower metabolism and reduced intake of nicotine from cigarette smoking in Chinese-Americans.
J Natl Cancer Inst. 2002 Jan 16;94(2):108-15. doi: 10.1093/jnci/94.2.108.
10
Applying the risk/use equilibrium: use medicinal nicotine now for harm reduction.
Tob Control. 2001 Sep;10(3):201-3. doi: 10.1136/tc.10.3.201.

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