一株强毒犬冠状病毒BGF株的分子特征分析
Molecular characterization of a virulent canine coronavirus BGF strain.
作者信息
Sanchez-Morgado Jose M, Poynter Scott, Morris Timothy H
机构信息
Laboratory Animal Science, GlaxoSmithkline, The Frythe, Welwyn, Herts AL6 9AR, UK.
出版信息
Virus Res. 2004 Aug;104(1):27-31. doi: 10.1016/j.virusres.2004.02.038.
Abstract
Molecular characterisation of a canine coronavirus (CCoV) isolate (BGF), associated with an outbreak of diarrhoea in puppies, showed 92.7% identity with attenuated Insavc-1 strain. Canine coronavirus BGF revealed a full length non-structural protein 3b (nsp 3b), associated with virulence in other coronaviruses, and a highly divergent region at the amino terminal domain of the membrane protein that may be implicated in avoiding the host immune reaction. This new canine coronavirus strain could help to identify virulence factors in coronavirus.
摘要
一种与幼犬腹泻暴发有关的犬冠状病毒（CCoV）分离株（BGF）的分子特征显示，其与减毒的Insavc-1株具有92.7%的同一性。犬冠状病毒BGF显示出与其他冠状病毒毒力相关的全长非结构蛋白3b（nsp 3b），以及膜蛋白氨基末端结构域的一个高度不同的区域，该区域可能与逃避宿主免疫反应有关。这种新的犬冠状病毒株有助于识别冠状病毒中的毒力因子。
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本文引用的文献
1
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J Virol Methods. 2003 Jun 9;110(1):9-17. doi: 10.1016/s0166-0934(03)00081-8.
2
Engineering the transmissible gastroenteritis virus genome as an expression vector inducing lactogenic immunity.
J Virol. 2003 Apr;77(7):4357-69. doi: 10.1128/jvi.77.7.4357-4369.2003.
3
M gene evolution of canine coronavirus in naturally infected dogs.
Vet Rec. 2002;151(25):758-61.
4
Identification of coronaviruses in dogs that segregate separately from the canine coronavirus genotype.
J Virol Methods. 2003 Feb;107(2):213-22. doi: 10.1016/s0166-0934(02)00246-x.
5
The virulence of mouse hepatitis virus strain A59 is not dependent on efficient spike protein cleavage and cell-to-cell fusion.
J Neurovirol. 2002 Oct;8(5):400-10. doi: 10.1080/13550280260422703.
6
Murine coronavirus spike glycoprotein mediates degree of viral spread, inflammation, and virus-induced immunopathology in the central nervous system.
Virology. 2002 Sep 15;301(1):109-20. doi: 10.1006/viro.2002.1551.
7
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J Clin Microbiol. 2002 Sep;40(9):3518-22. doi: 10.1128/JCM.40.9.3518-3522.2002.
8
Interaction of the coronavirus nucleoprotein with nucleolar antigens and the host cell.
J Virol. 2002 May;76(10):5233-50. doi: 10.1128/jvi.76.10.5233-5250.2002.
9
Transcription regulatory sequences and mRNA expression levels in the coronavirus transmissible gastroenteritis virus.
J Virol. 2002 Feb;76(3):1293-308. doi: 10.1128/jvi.76.3.1293-1308.2002.
10
The PROSITE database, its status in 2002.
Nucleic Acids Res. 2002 Jan 1;30(1):235-8. doi: 10.1093/nar/30.1.235.
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