Watanabe Akihiro, Kawajiri Masakazu, Ikezoe Koji, Osoegawa Manabu, Murai Hiroyuki, Ochi Hirofumi, Taniwaki Takayuki, Kira Jun-ichi
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukoada 812-8582, Japan.
J Neurol Sci. 2004 Jun 15;221(1-2):95-7. doi: 10.1016/j.jns.2004.02.012.
Two adult females developed HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and psoriasis. Both showed chronic progressive paraparesis and sharply demarcated erythematous scaling plaques on their extremities and trunk. One patient had polymyositis while in the other anti-thyroid antibodies, antinuclear antibodies and SS-A antibody, all autoantibodies, were positive. Both patients were treated by intramuscular injections of interferon-alpha for 2 to 4 weeks, resulting in amelioration of paraparesis. After the therapy psoriasis and polymyositis markedly improved in one patient without any additional therapy, while in the other simultaneous use of topical corticosteroids was effective. This is the first report to describe occurrences of psoriasis in HAM/TSP patients. Although there are several reports indicating interferon-alpha induces or exacerbates psoriasis, our experience suggests that psoriasis associated with HAM/TSP can be successfully managed even during interferon-alpha therapy.
两名成年女性患上了人类嗜T淋巴细胞病毒1型相关脊髓病/热带痉挛性截瘫（HAM/TSP）和银屑病。两人均表现为慢性进行性截瘫，四肢及躯干出现边界清晰的红斑鳞屑性斑块。其中一名患者患有多发性肌炎，另一名患者的抗甲状腺抗体、抗核抗体和SS - A抗体（均为自身抗体）呈阳性。两名患者均接受了为期2至4周的肌肉注射α干扰素治疗，截瘫症状有所改善。治疗后，其中一名患者的银屑病和多发性肌炎在未进行任何额外治疗的情况下显著改善，而另一名患者同时使用外用糖皮质激素则有效。这是首篇描述HAM/TSP患者出现银屑病的报告。尽管有几份报告表明α干扰素会诱发或加重银屑病，但我们的经验表明，即使在α干扰素治疗期间，与HAM/TSP相关的银屑病也能得到成功治疗。
