Research centre for Cutaneous Leishmaniasis, Department of Dermatology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Internal Medicine ,Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran J Basic Med Sci. 2013 Mar;16(3):273-7.
OBJECTIVE(S): Infection with the human T-cell lymphotrophic virus type-I (HTLV-I) is endemic in Mashhad, Iran. In our research we evaluated the relation between exposure to this infection and the occurrence of dermatologic manifestations.
100 blood donors, who were seropositive but asymptomatic for infection with HTLV-I, were selected as case group. They were identified by the Blood Transfusion Organization Mashhad via the ELISA test and documented by PCR. Another 100 blood donors, that were seronegative for HTLV-I via the ELISA test and who were matched to the case group for age, gender, and existence of systemic diseases, were considered as the controls. Dermatologic evaluations and skin biopsies were performed if deemed necessary, and the results were statistically analyzed.
73% of the case and control groups were male, while 27% in each of these groups were female. The mean age in both groups was 40.96±11.94 years. The examination indicated that 58% of the case group and 37% of the control group had cutaneous manifestations (P<0.01). The most common diseases found in the case group were aphthous stomatitis, herpes labialis, and non-genital warts, while common diseases found in the control group were herpes labialis, aphthous stomatitis, and skin tag. The frequency of aphthous stomatitis, eczema, and non-genital warts in the case group were significantly more than the control group (P<0.05). Conclusion : Cutaneous diseases can be found more frequent in asymptomatic carriers of HTLV-I than those who are HTLV-I seronegative. The aphthous stomatitis, eczema, and non-genital warts are more prevalent in those infected by HTLV-I.
伊朗马什哈德地区存在人类 T 细胞嗜淋巴细胞病毒 1 型（HTLV-I）感染。本研究旨在评估感染与皮肤科表现发生之间的关系。
选择 100 名 HTLV-I 血清阳性但无症状的献血者作为病例组。这些献血者是由马什哈德输血组织通过 ELISA 检测发现的，并通过 PCR 进行了确认。另外选择 100 名 HTLV-I 血清学 ELISA 阴性且与病例组在年龄、性别和系统性疾病方面相匹配的献血者作为对照组。如果需要，对所有献血者进行皮肤科评估和皮肤活检，并对结果进行统计学分析。
病例组和对照组中分别有 73%和 27%为男性，分别有 27%和 73%为女性。两组的平均年龄分别为 40.96±11.94 岁。检查结果显示，病例组中 58%和对照组中 37%的人有皮肤表现（P<0.01）。病例组中最常见的疾病是口腔溃疡、唇疱疹和非生殖器疣，而对照组中最常见的疾病是唇疱疹、口腔溃疡和皮肤标签。病例组中口腔溃疡、湿疹和非生殖器疣的发病率明显高于对照组（P<0.05）。
与 HTLV-I 血清阴性者相比，无症状 HTLV-I 携带者更易出现皮肤疾病。感染 HTLV-I 的人群中，口腔溃疡、湿疹和非生殖器疣更为常见。
