Loginov A S, Sharafanova T I, Reshetniak V I, Il'chenko L Iu, Shepeleva S D, Serova T I, Tkachev V D
Ter Arkh. 2000;72(11):9-13.
To examine clinical, immunological and morphological features of HGV- and TTV-infections in patients with chronic hepatic diseases (CHD) and assess efficiency of treatment of HGV-seropositive patients.
202 patients with CHD were examined for markers of HBV-, HCV-, HGV- and TTV-infections. Some patients were subjected to puncture biopsy of the liver. Efficiency of interferon-alpha treatment of HGV and HBV/HCV coinfection was studied.
HGV RNA and TTV DNA were detected in 19.8 and 11.8% of cases, respectively. Biochemical indices in patients with HGV and TTV monoinfections significantly differed from those in the control group while morphological changes in most of them corresponded to those with hepatitis. INF-alpha was given to 7 patients with HGV + HBV/HCV infections. A response was achieved in 3 months in 2 of them.
The role of HGV and TTV in hepatic diseases pathology is still unclear. Further studies on detection and examination of patients infected with G and TT viruses are necessary. When choosing therapy, the presence of HGV RNA and TTV DNA in blood serum, virus genome in hepatocytes and histological changes in hepatic tissue should be considered.
研究慢性肝病（CHD）患者中庚型肝炎病毒（HGV）和输血传播病毒（TTV）感染的临床、免疫学及形态学特征，并评估HGV血清阳性患者的治疗效果。
对202例CHD患者进行了乙肝病毒（HBV）、丙肝病毒（HCV）、HGV及TTV感染标志物检测。部分患者接受了肝脏穿刺活检。研究了α干扰素治疗HGV感染及HBV/HCV合并感染的效果。
分别在19.8%和11.8%的病例中检测到HGV RNA和TTV DNA。HGV和TTV单一感染患者的生化指标与对照组显著不同，而其中大多数患者的形态学改变与肝炎患者相符。对7例HGV + HBV/HCV合并感染患者给予α干扰素治疗。其中2例在3个月时出现了反应。
HGV和TTV在肝脏疾病病理中的作用仍不明确。有必要对感染G病毒和TT病毒的患者进行进一步的检测和研究。在选择治疗方案时，应考虑血清中HGV RNA和TTV DNA的存在、肝细胞中的病毒基因组以及肝组织的组织学变化。
