Golay A, Buclin S, Ybarra J, Toti F, Pichard C, Picco N, de Tonnac N, Allaz A F
Division of Therapeutic Education for Chronic Diseases, Geneva University Hospital, Switzerland.
Eat Weight Disord. 2004 Mar;9(1):29-34. doi: 10.1007/BF03325042.
The aim of this prospective case-control study was to assess the long-term effectiveness of interdisciplinary cognitive-behavioural-nutritional therapy, combined with daily physical exercise and relaxation sessions, on weight and psychosocial issues during a 6-week in-hospital stay.
Five years (60 +/- 1 months) later, the patients were readmitted for a one-day medical evaluation including a physical examination and laboratory work-up, and the completion of a detailed questionnaire focusing on dietary and psychosocial factors that may affect weight loss/regain.
The follow-up population consisted of 55 morbidly obese subjects aged 49.5 +/- 2 years (45 females and 10 males; BMI: 40 +/- 0.7 kg/m2). During their initial 6-week in-hospital stay, they lost an average of 7.6 +/- 0.4 kg.
Five years later, 25.5% of the patients had lost a further 11.9 +/- 1.8 kg, 20% maintained their initial weight loss (0.6 +/- 0.4 kg), and 54.5% regained weight (10.4 +/- 1 kg). The weight changes significant correlated with the degree of psychosocial difficulties (p < 0.001), eating behaviour problems (p < 0.001), dietary fat intake (p < 0.005) and total energy intake (p < 0.05). Fasting plasma insulin and blood glucose concentrations were significantly higher in the patients who regained weight after five years, and significantly lower in those who had lost more weight.
As a whole, these results show the efficacy of an interdisciplinary approach to the long-term treatment of morbidly obese patients. It is likely that an outpatient psychological follow-up would have improved this therapeutic success.
这项前瞻性病例对照研究的目的是评估跨学科认知行为营养疗法,结合日常体育锻炼和放松训练,在为期6周的住院期间对体重和心理社会问题的长期疗效。
五年(60±1个月)后,患者再次入院进行为期一天的医学评估,包括体格检查和实验室检查,并完成一份详细问卷,重点关注可能影响体重减轻/反弹的饮食和心理社会因素。
随访人群包括55名病态肥胖受试者,年龄49.5±2岁(45名女性和10名男性;BMI:40±0.7kg/m²)。在最初6周的住院期间,他们平均体重减轻了7.6±0.4kg。
五年后,25.5%的患者体重进一步减轻了11.9±1.8kg,20%的患者维持了最初的体重减轻(0.6±0.4kg),54.5%的患者体重反弹(10.4±1kg)。体重变化与心理社会困难程度(p<0.001)、饮食行为问题(p<0.001)、膳食脂肪摄入量(p<0.005)和总能量摄入量(p<0.05)显著相关。五年后体重反弹的患者空腹血浆胰岛素和血糖浓度显著更高,而体重减轻更多的患者则显著更低。
总体而言,这些结果表明跨学科方法对病态肥胖患者的长期治疗是有效的。门诊心理随访可能会提高这种治疗效果。