皮质-基底神经节通路中的网络水平神经可塑性。
Network-level neuroplasticity in cortico-basal ganglia pathways.
作者信息
Graybiel Ann M
机构信息
Department of Brain and Cognitive Sciences, McGovern Institute for Brain Research, Massachusetts Institute of Technology, 45 Carleton Street, E25-618, Cambridge, MA 02139, USA.
出版信息
Parkinsonism Relat Disord. 2004 Jul;10(5):293-6. doi: 10.1016/j.parkreldis.2004.03.007.
The striatum, the largest input nucleus of the basal ganglia, receives massive inputs from the neocortex and thalamus, and gives rise to the direct, indirect and striosomal pathways of the basal ganglia. Here, the view is developed that the striatum is a major site for adaptive plasticity in cortico-basal ganglia circuits, affecting in the normal state a broad range of behaviours. This plasticity can become a major source of maladaptive responses in disease states affecting the basal ganglia.
纹状体是基底神经节最大的输入核团，接收来自新皮层和丘脑的大量输入，并产生基底神经节的直接、间接和纹状小体通路。本文提出一种观点，即纹状体是皮质 - 基底神经节回路中适应性可塑性的主要位点，在正常状态下影响广泛的行为。在影响基底神经节的疾病状态下，这种可塑性可能成为适应不良反应的主要来源。
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