Xu Rui-rong, Cao Fang, Liu Zhao-xia
Affiliated Hospital of Shandong University of TCM, Jinan 250011.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 May;24(5):411-4.
To observe the clinical efficacy of TCM with supplementing Qi, nourishing Yin and clearing heat principle (SQNYCH) combined with chemotherapy in treating myelocytic leukemia.
One hundred and fourteen patients were randomly divided into the treated group (n = 68) and the control group (n = 46). To the treated group, SQNYCH was applied as the basic treatment, with combined chemotherapeutic protocol, using DA, HA and IA, to induce remission, and to the M3 patients, all-trans retinoic acid and arsenic trioxide were given. As for patients in the control group, only western medicine was administered.
In the treated group 49 patients (72.1%) were completely remitted, 9 (13.2%) partially remitted and the total remission rate being 85.3%, which was significantly different from that in the control group. After treatment, the blood and bone marrow picture were obviously improved in both groups, but the increase of hemoglobin and platelet were better in the treated group than in the control group (P < 0.05 or P < 0.01). Immune functions were enhanced in both groups, but the elevation of CD4, CD4/CD8 ratio and NK cells were higher in the treated group than in the control group (P < 0.05 and P < 0.01).
Application of SQNYCH principle in treating acute myelocytic leukemia could elevate the clinical efficacy, which is of great value in clinical practice.
观察益气养阴清热法（SQNYCH）联合化疗治疗髓细胞白血病的临床疗效。
114例患者随机分为治疗组（n = 68）和对照组（n = 46）。治疗组采用益气养阴清热法作为基础治疗，联合化疗方案，使用DA、HA和IA诱导缓解，M3型患者给予全反式维甲酸和三氧化二砷。对照组仅给予西药治疗。
治疗组49例（72.1%）完全缓解，9例（13.2%）部分缓解，总缓解率为85.3%，与对照组差异有统计学意义。治疗后两组血常规及骨髓象均明显改善，但治疗组血红蛋白及血小板升高情况优于对照组（P < 0.05或P < 0.01）。两组免疫功能均增强，但治疗组CD4、CD4/CD8比值及NK细胞升高幅度高于对照组（P < 0.05和P < 0.01）。
益气养阴清热法应用于急性髓细胞白血病治疗可提高临床疗效，在临床实践中有重要价值。
