Maezaki Naoyoshi, Hirose Yuki, Tanaka Tetsuaki
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
Org Lett. 2004 Jun 24;6(13):2177-80. doi: 10.1021/ol049374d.
[reaction: see text] Highly stereoselective synthesis of 1,4-bifunctional compounds was accomplished via 1,2-asymmetric induction to alpha-oxyaldehyde followed by regio- and diastereoselective Pd-catalyzed allylic substitution reaction.
[反应：见正文] 通过对α-氧代醛进行1,2-不对称诱导，然后进行区域和非对映选择性钯催化的烯丙基取代反应，实现了1,4-双官能团化合物的高度立体选择性合成。
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