Thu Hlaing Myat, Lowry Kym, Myint Thein Thein, Shwe Than Nu, Han Aye Maung, Khin Kyu Kyu, Thant Kyaw Zin, Thein Soe, Aaskov John
Queensland University of Technology, Brisbane, Australia.
Emerg Infect Dis. 2004 Apr;10(4):593-7. doi: 10.3201/eid1004.030216.
In 2001, Myanmar (Burma) had its largest outbreak of dengue-15,361 reported cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), including 192 deaths. That year, 95% of dengue viruses isolated from patients were serotype 1 viruses belonging to two lineages that had diverged from an earlier, now extinct, lineage sometime before 1998. The ratio of DHF to DSS cases in 2001 was not significantly different from that in 2000, when 1,816 cases of DHF/DSS were reported and dengue 1 also was the most frequently isolated serotype. However, the 2001 ratio was significantly higher than that in 1998 (also an outbreak year) and in 1999, when all four serotypes were detected and serotypes 1, 2, and 3 were recovered in similar numbers. The large number of clinical cases in 2001 may have been due, in part, to a preponderance of infections with dengue 1 viruses.
2001年，缅甸爆发了最大规模的登革热疫情，报告了15361例登革出血热/登革休克综合征（DHF/DSS）病例，其中包括192例死亡病例。同年，从患者身上分离出的登革病毒中，95% 是1型病毒，它们属于两个谱系，这两个谱系在1998年之前的某个时间从一个早期的、现已灭绝的谱系分化而来。2001年DHF与DSS病例的比例与2000年相比没有显著差异，2000年报告了1816例DHF/DSS病例，1型登革热也是最常分离出的血清型。然而，2001年的比例显著高于1998年（同样是疫情爆发年份）和1999年，1999年检测到了所有四种血清型，1、2和3型血清型的检出数量相近。2001年大量的临床病例可能部分归因于感染1型登革病毒的情况占多数。
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