Valencia A, Collado P, Calés J M, Segovia S, Pérez Laso C, Rodríguez Zafra M, Guillamón A
Departamento de Psicobiología, Universidad Nacional de Educación a Distancia, Ciudad Universitaria, Madrid, Spain.
Brain Res Dev Brain Res. 1992 Jul 24;68(1):132-5. doi: 10.1016/0165-3806(92)90255-u.
The regulatory action of the non-aromatizable androgen dihydrotestosterone (DHT) on sexual differentiation of the volume of the rat accessory olfactory bulb (AOB) was studied. Postnatal treatment with DHT (180 micrograms/day) carried out daily between days 6 and 20 produced a drastic reduction in overall AOB size and that of its constituent neural layers in genetic males with respect to intact and control males. The volumetric measures found in DHT-treated males did not differ from those shown by the intact females. These results, which indicate a demasculinization and a feminization of the AOB volume in gonadally intact male rats induced by DHT, are discussed in relation to the presumably regulatory role of DHT on neuron populations during the sexual organizational process of the brain.
研究了非芳香化雄激素双氢睾酮（DHT）对大鼠副嗅球（AOB）体积性分化的调节作用。在出生后第6天至第20天期间每天用DHT（180微克/天）进行处理，与完整和对照雄性相比，导致基因雄性大鼠的整个AOB大小及其组成神经层的大小急剧减小。经DHT处理的雄性大鼠的体积测量结果与完整雌性大鼠的测量结果没有差异。这些结果表明，在性腺完整的雄性大鼠中，DHT诱导了AOB体积的去雄性化和雌性化，本文结合DHT在大脑性组织过程中对神经元群体可能的调节作用对这些结果进行了讨论。
