Capon Robert J, Skene Colin, Liu Edward H, Lacey Ernest, Gill Jennifer H, Heiland Kirstin, Friedel Thomas
School of Chemistry, University of Melbourne, Parkville, Victoria 3010, Australia.
Nat Prod Res. 2004 Aug;18(4):305-9. doi: 10.1080/14786410310001620619.
Bioassay directed fractionation of a Raspailia (Raspailia) sp. (Order Poecilosclerida; Family Raspailiidae) collected during scientific trawling operations off the Northern Rottnest Shelf yielded as nematocidal agents the known metabolites, phorboxazoles A (1) and B (2). Further examination revealed the new natural product but known synthetic compound, esmodil (3). The structure for 3 was confirmed by spectroscopic analysis and total synthesis.
在罗特内斯特岛北部大陆架海域的科学拖网作业中采集到的一种拉氏海绵（拉氏海绵属，Poecilosclerida目，拉氏海绵科），通过生物测定导向的分级分离得到了已知代谢产物——海兔毒素A（1）和B（2）作为杀线虫剂。进一步研究发现了新的天然产物但却是已知的合成化合物——埃斯莫迪尔（3）。通过光谱分析和全合成确定了3的结构。
