Missimer John, Madi Zoltan, Honer Michael, Keller Claudia, Schubiger August, Ametamey Simon-Mensah
Biomolecular Research and Center for Radiopharmaceutical Science of PSI, ETH and USZ, Life Sciences Division, Paul Scherrer Institute, 5232 Villigen, Switzerland.
Phys Med Biol. 2004 May 21;49(10):2069-81. doi: 10.1088/0031-9155/49/10/016.
The quad-HIDAC small animal PET camera is a quadratic array of high-density avalanche chambers; the camera described in this publication consists of 16 modules. We present the system response using point and line sources and a mouse phantom. The quad-HIDAC camera exhibits a count rate stability of better than 1% and linearity of response to coincidences up to 2.2 x 10(5) cps at 16 MBq activity. Corrected for deadtime and random coincidences, the efficiency for the line source is 0.011, of which unscattered coincidences yield 0.009. The scatter fraction originating from the detectors is 0.22. Absorption within the mouse phantom was 20% and the scatter fraction increased to 0.29. Resolution is uniform within the entire field-of-view, which is 28 cm axially and 17 cm radially. Reconstruction of a point source yields a resolution of 1.1 mm FWHM for all three components. The performance of the camera demonstrates its excellent suitability for the functional imaging of small animals.
四象限高分辨雪崩室小动物正电子发射断层显像仪是一种由高密度雪崩室组成的二次阵列；本出版物中描述的相机由16个模块组成。我们使用点源、线源和小鼠模型展示了该系统的响应。四象限高分辨雪崩室相机在16 MBq活度下，计数率稳定性优于1%，对符合事件的响应线性度高达2.2×10⁵ cps。经死时间和随机符合校正后，线源效率为0.011，其中无散射符合事件的效率为0.009。探测器产生的散射分数为0.22。小鼠模型内的吸收为20%，散射分数增加到0.29。在整个视野范围内分辨率均匀，轴向视野为28 cm，径向视野为17 cm。点源重建对所有三个分量的分辨率为1.1 mm半高宽。该相机的性能表明其非常适合小动物的功能成像。
