用于莱姆病螺旋体病小鼠模型中预防蜱叮咬感染的盐酸多西环素缓释制剂
Sustained-release formulation of doxycycline hyclate for prophylaxis of tick bite infection in a murine model of Lyme borreliosis.
作者信息
Zeidner N S, Brandt K S, Dadey E, Dolan M C, Happ C, Piesman J
机构信息
Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, P.O. Box 2087, Rampart Rd., Foothill Campus, Fort Collins, CO 80522, USA.
出版信息
Antimicrob Agents Chemother. 2004 Jul;48(7):2697-9. doi: 10.1128/AAC.48.7.2697-2699.2004.
Abstract
The prophylactic potential of a single injection of sustained-release doxycycline hyclate (Atridox) was compared to that of a single oral dose of doxycycline hyclate in a murine model of Lyme borreliosis. Prophylaxis, as measured by the lack of cultivable spirochetes and demonstrable pathology, was noted for 43% of orally treated mice; in contrast, the sustained-release doxycycline hyclate completely protected mice from infection and resultant pathology.
摘要
在莱姆病螺旋体病的小鼠模型中，将单次注射缓释型盐酸多西环素（Atridox）的预防潜力与单次口服盐酸多西环素的预防潜力进行了比较。通过无可培养的螺旋体和可证实的病理学表现来衡量预防效果，口服治疗的小鼠中有43%出现了预防效果；相比之下，缓释型盐酸多西环素完全保护小鼠免受感染及由此产生的病理学变化。
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