用于基因组序列多重比对的CHAOS/DIALIGN万维网服务器。
The CHAOS/DIALIGN WWW server for multiple alignment of genomic sequences.
作者信息
Brudno Michael, Steinkamp Rasmus, Morgenstern Burkhard
机构信息
Department of Computer Science, Stanford University, Stanford, CA 94305, USA.
出版信息
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W41-4. doi: 10.1093/nar/gkh361.
Abstract
Cross-species sequence comparison is a powerful approach to analyze functional sites in genomic sequences and many discoveries have been made based on genomic alignments. Herein, we present a WWW-based software system for multiple alignment of large genomic sequences. Our server utilizes the previously developed combination of CHAOS and DIALIGN to achieve both speed and alignment accuracy. CHAOS is a fast database search tool that creates a list of local sequence similarities. These are used by DIALIGN as anchor points to speed up the final alignment procedure. The resulting alignment is returned to the user in different formats together with a list of anchor points found by CHAOS. The CHAOS/DIALIGN software is freely available at http://dialign.gobics.de/chaos-dialign-submission.
摘要
跨物种序列比较是分析基因组序列中功能位点的一种强大方法，并且基于基因组比对已经有了许多发现。在此，我们展示了一个基于万维网的用于大型基因组序列多重比对的软件系统。我们的服务器利用先前开发的CHAOS和DIALIGN的组合来实现速度和比对准确性。CHAOS是一个快速的数据库搜索工具，它创建局部序列相似性列表。DIALIGN将这些用作锚点来加速最终的比对过程。最终的比对结果会以不同格式返回给用户，并附带CHAOS找到的锚点列表。CHAOS/DIALIGN软件可在http://dialign.gobics.de/chaos-dialign-submission免费获取。
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