Department of Bioinformatics, University of Göttingen, Institute of Microbiology and Genetics, Goldschmidtstr. 1, 37077 Göttingen, Germany.
Nucleic Acids Res. 2013 Jul;41(Web Server issue):W3-7. doi: 10.1093/nar/gkt283. Epub 2013 Apr 24.
DIALIGN is an established tool for multiple sequence alignment that is particularly useful to detect local homologies in sequences with low overall similarity. In recent years, various versions of the program have been developed, some of which are fully automated, whereas others are able to accept user-specified external information. In this article, we review some versions of the program that are available through 'Göttingen Bioinformatics Compute Server'. In addition to previously described implementations, we present a new release of DIALIGN called 'DIALIGN-PFAM', which uses hits to the PFAM database for improved protein alignment. Our software is available through http://dialign.gobics.de/.
DIALIGN 是一种成熟的多序列比对工具，特别适用于检测整体相似度较低的序列中的局部同源性。近年来，该程序的各种版本已经开发出来，其中一些是完全自动化的，而另一些则能够接受用户指定的外部信息。在本文中，我们回顾了可通过“哥廷根生物信息学计算服务器”获得的该程序的一些版本。除了之前描述的实现方式，我们还展示了一个名为“DIALIGN-PFAM”的 DIALIGN 新版本，它使用 PFAM 数据库的命中来改进蛋白质比对。我们的软件可通过 http://dialign.gobics.de/ 获得。
