建议：通过协同进化进行交互的自动检测与验证
ADVICE: Automated Detection and Validation of Interaction by Co-Evolution.
作者信息
Tan Soon-Heng, Zhang Zhuo, Ng See-Kiong
机构信息
Knowledge Discovery Department, Institute for Infocomm Research, 21 Heng Mui Keng Terrace, Singapore 119613, Singapore.
出版信息
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W69-72. doi: 10.1093/nar/gkh471.
ADVICE (Automated Detection and Validation of Interaction by Co-Evolution) is a web tool for predicting and validating protein-protein interactions using the observed co-evolution between interacting proteins. Interacting proteins are known to share similar evolutionary histories since they undergo coordinated evolutionary changes to preserve interactions and functionalities. The web tool automates a commonly adopted methodology to quantify the similarities in proteins' evolutionary histories for postulating potential protein-protein interactions. ADVICE can also be used to validate experimental data against spurious protein interactions by identifying those that have few similarities in their evolutionary histories. The web tool accepts a list of protein sequences or sequence pairs as input and retrieves orthologous sequences to compute the similarities in the proteins' evolutionary histories. To facilitate hypothesis generation, detected co-evolved proteins can be visualized as a network at the website. ADVICE is available at http://advice.i2r.a-star.edu.sg.
ADVICE（通过协同进化实现相互作用的自动检测与验证）是一种网络工具，用于利用观察到的相互作用蛋白质之间的协同进化来预测和验证蛋白质-蛋白质相互作用。已知相互作用的蛋白质具有相似的进化历史，因为它们会经历协调的进化变化以维持相互作用和功能。该网络工具自动化了一种常用方法，用于量化蛋白质进化历史中的相似性，以推测潜在的蛋白质-蛋白质相互作用。ADVICE还可用于通过识别那些在进化历史中相似性较少的相互作用，来针对虚假蛋白质相互作用验证实验数据。该网络工具接受蛋白质序列或序列对列表作为输入，并检索直系同源序列以计算蛋白质进化历史中的相似性。为便于生成假设，在网站上可将检测到的协同进化蛋白质可视化为网络。可通过http://advice.i2r.a-star.edu.sg访问ADVICE。
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