PRED-GPCR：G蛋白偶联受体识别与家族分类服务器。

PRED-GPCR: GPCR recognition and family classification server.

作者信息

Papasaikas P K, Bagos P G, Litou Z I, Promponas V J, Hamodrakas S J

机构信息

Department of Cell Biology and Biophysics, Faculty of Biology, University of Athens, Panepistimiopolis, Athens 157 01, Greece.

出版信息

Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W380-2. doi: 10.1093/nar/gkh431.

DOI:10.1093/nar/gkh431

PMID:15215415

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC441569/

Abstract

The vast cell-surface receptor family of G-protein coupled receptors (GPCRs) is the focus of both academic and pharmaceutical research due to their key role in cell physiology along with their amenability to drug intervention. As the data flow rate from the various genome and proteome projects continues to grow, so does the need for fast, automated and reliable screening for new members of the various GPCR families. PRED-GPCR is a free Internet service for GPCR recognition and classification at the family level. A submitted sequence or set of sequences, is queried against the PRED-GPCR library, housing 265 signature profile HMMs corresponding to 67 well-characterized GPCR families. Users query the server through a web interface and results are presented in HTML output format. The server returns all single-motif matches along with the combined results for the corresponding families. The service is available online since October 2003 at http://bioinformatics.biol.uoa.gr/PRED-GPCR.

摘要

G蛋白偶联受体（GPCRs）庞大的细胞表面受体家族是学术研究和药物研发的焦点，因为它们在细胞生理学中发挥关键作用，并且易于进行药物干预。随着来自各种基因组和蛋白质组计划的数据流率不断增长，对各种GPCR家族新成员进行快速、自动化和可靠筛选的需求也在增加。PRED-GPCR是一项免费的互联网服务，用于在家族水平上识别和分类GPCR。将提交的一个或一组序列与PRED-GPCR文库进行比对，该文库包含对应于67个特征明确的GPCR家族的265个特征谱隐马尔可夫模型（HMMs）。用户通过网页界面查询服务器，结果以HTML输出格式呈现。服务器返回所有单基序匹配结果以及相应家族的综合结果。该服务自2003年10月起可在线获取，网址为http://bioinformatics.biol.uoa.gr/PRED-GPCR 。

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