Fu Yutao, Frith Martin C, Haverty Peter M, Weng Zhiping
Bioinformatics Program, Boston University, Boston, MA 02215, USA.
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W420-3. doi: 10.1093/nar/gkh426.
Detecting overrepresented known transcription factor binding motifs in a set of promoter sequences of co-regulated genes has become an important approach to deciphering transcriptional regulatory mechanisms. In this paper, we present an interactive web server, MotifViz, for three motif discovery programs, Clover, Rover and Motifish, covering most available flavors of algorithms for achieving this goal. For comparison, we have also implemented the simple motif-matching program Possum. MotifViz provides uniform and intuitive input and output formats for all four programs. It can be accessed at http://biowulf.bu.edu/MotifViz.
在一组共同调控基因的启动子序列中检测过度富集的已知转录因子结合基序，已成为破译转录调控机制的一种重要方法。在本文中，我们为三个基序发现程序Clover、Rover和Motifish展示了一个交互式网络服务器MotifViz，涵盖了实现这一目标的大多数可用算法类型。为了进行比较，我们还实现了简单的基序匹配程序Possum。MotifViz为所有四个程序提供统一且直观的输入和输出格式。可通过http://biowulf.bu.edu/MotifViz访问该服务器。
