Rollins M D, Jenkins J G, Carson D J, McClure B G, Mitchell R H, Imam S Z
Royal Belfast Hospital for Sick Children, Department of Child Health, Queen's University of Belfast, Northern Ireland.
Diabetologia. 1992 May;35(5):452-5. doi: 10.1007/BF02342443.
In recent years it has been shown that alteration in heart rate variability can be used for the objective assessment of autonomic function in adult diabetic patients. Using a microcomputer based system for on-line monitoring and analysis of heart rate variability by power spectral analysis, 100 children with Type 1 (insulin-dependent) diabetes mellitus were studied. A highly significant negative correlation was identified between heart rate variability and duration of diabetes (r = -0.88, p less than 0.0001). The mean heart rate variability in patients with diabetes of duration 3 years or more was significantly lower in comparison to age-matched control subjects. A highly significant negative correlation was evident between heart rate variability and mean HbA1 in patients with duration of diabetes of 5 years or more. A mean HbA1 over 10% during this period was associated with the greatest reduction in heart rate variability. Serial measurements of heart rate variability in diabetic children may be of predictive value prior to the onset of symptomatic neuropathy.
近年来研究表明，心率变异性的改变可用于客观评估成年糖尿病患者的自主神经功能。采用基于微型计算机的系统，通过功率谱分析对心率变异性进行在线监测和分析，对100例1型（胰岛素依赖型）糖尿病患儿进行了研究。发现心率变异性与糖尿病病程之间存在高度显著的负相关（r = -0.88，p < 0.0001）。病程3年及以上的糖尿病患者的平均心率变异性与年龄匹配的对照受试者相比显著降低。病程5年及以上的患者中，心率变异性与平均糖化血红蛋白（HbA1）之间存在高度显著的负相关。在此期间，平均HbA1超过10%与心率变异性的最大降低相关。对糖尿病患儿进行心率变异性的系列测量可能在症状性神经病变发作之前具有预测价值。
