Kruszewski Marcin
Department of Radiobiology and Health Protection, Institute of Nuclear Chemistry and Technology, Warszawa, Poland.
Acta Biochim Pol. 2004;51(2):471-80.
Although multiple factors are associated with cardiovascular pathology, there is now an impressive body of evidence that free radicals and nonradical oxidants might cause a number of cardiovascular dysfunctions. Both direct damage to cellular components and/or oxidation of extracellular biomolecules, e.g. LDL, might be involved in the aetiology of cardiovascular diseases. The key molecules in this process seem to be iron and copper ions that catalyse formation of the highly reactive hydroxyl radical. Chelation of iron ions has a beneficial effect on the processes associated with the development of atherosclerosis and formation of post-ischemic lesions. These findings are indirectly supported by the increasing body of evidence that stored body iron plays a crucial role in pathogenesis of atherosclerosis and ischemia/reperfusion injury.
尽管多种因素与心血管病理相关，但现在有大量令人瞩目的证据表明，自由基和非自由基氧化剂可能会导致多种心血管功能障碍。对细胞成分的直接损伤和/或细胞外生物分子（如低密度脂蛋白）的氧化，可能都参与了心血管疾病的病因形成。这一过程中的关键分子似乎是铁离子和铜离子，它们催化高反应性羟基自由基的形成。铁离子螯合对与动脉粥样硬化发展和缺血后病变形成相关的过程具有有益作用。越来越多的证据间接支持了这些发现，即体内储存的铁在动脉粥样硬化发病机制和缺血/再灌注损伤中起着关键作用。
