Khanna A K, Chander R, Singh C, Srivastava A K, Kapoor N K
Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
Indian J Exp Biol. 1992 Feb;30(2):128-30.
The alcoholic extract of A. aspera, at 100 mg/kg dose lowered serum cholesterol (TC), phospholipid (PL). triglyceride (TG) and total lipids (TL) levels by 60, 51, 33 and 53% respectively in triton induced hyperlipidemic rats. The chronic administration of this drug at the same doses to normal rats for 30 days, lowered serum TC, PL, TG and TL by 56, 62, 68 and 67% respectively followed by significant reduction in the levels of hepatic lipids. The faecal excretion of cholic acid and deoxycholic acid increased by 24 and 40% respectively under the action of this drug. The possible mechanism of action of cholesterol lowering activity of A. aspera may be due to rapid excretion of bile acids causing low absorption of cholesterol.
在 Triton 诱导的高脂血症大鼠中，糙叶榕乙醇提取物以 100mg/kg 的剂量分别使血清胆固醇（TC）、磷脂（PL）、甘油三酯（TG）和总脂质（TL）水平降低了 60%、51%、33%和 53%。以相同剂量对正常大鼠连续给药 30 天，血清 TC、PL、TG 和 TL 分别降低了 56%、62%、68%和 67%，随后肝脏脂质水平显著降低。在该药物作用下，胆酸和脱氧胆酸的粪便排泄量分别增加了 24%和 40%。糙叶榕降胆固醇活性的可能作用机制可能是由于胆汁酸快速排泄导致胆固醇吸收减少。
