Sovová M, Sova P
Katedra farmaceutické botaniky a ekologie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové.
Ceska Slov Farm. 2004 May;53(3):117-23.
The paper summarizes the knowledge on the antihyperlipidemic effect of garlic, formulations prepared from it, and the individual components, which were obtained prevalently in recent decade. It presents varying opinions based on experimental results concerning the mechanisms by means of which the effect takes place. In vitro experiments were carried out mainly on the cultures of rat hepatocytes and an inhibitory effect on important enzymic activities taking place in the biosynthesis of cholesterol and fatty acids was demonstrated. The most frequently employed in vivo models were rabbits. The antiatheraogenic effect was markedly manifested by a reduction of lipid plaques in the arteries in hypercholesterolemic animals, decreased accumulation of cholesterol in vascular walls, and other positive interventions.
本文总结了近十年来关于大蒜及其制剂和单一成分的降血脂作用的知识。基于大蒜降血脂作用机制的实验结果，文中呈现了不同的观点。体外实验主要在大鼠肝细胞培养物上进行，结果表明大蒜对胆固醇和脂肪酸生物合成过程中的重要酶活性具有抑制作用。体内实验最常用的模型是兔子。在高胆固醇血症动物中，大蒜的抗动脉粥样硬化作用显著表现为动脉脂质斑块减少、血管壁胆固醇积累降低以及其他积极作用。
