Mohammad Abdel R, Giannini Peter J, Preshaw Philip M, Alliger Howard
The Ohio State University College of Dentistry, Section of Primary Care, Postle Hall Office 3058, 305 West 12th Avenue, Columbus, OH 43210, USA.
Int Dent J. 2004 Jun;54(3):154-8. doi: 10.1111/j.1875-595x.2004.tb00272.x.
To assess the clinical and microbiological efficacy of chlorine dioxide (ClO2) as a topical antiseptic for the treatment of chronic atrophic candidiasis in geriatric patients.
Thirty patients with chronic atrophic candidiasis.
Patients were instructed to rinse the mouth with 0.8% ClO2 mouth rinse (DioxiDent) twice daily for one minute and to soak their dentures overnight in the ClO2 for 10 days. Patients were evaluated both clinically and microbiologically at baseline and after 10 days, and any significant side effects were recorded. The clinical appearance of the oral soft tissues was scored on a scale of 0-3 (0 indicating no clinical signs, 1 indicating involvement of < 25% of the palatal mucosa, 2 indicating involvement of 25-50% of the palatal mucosa, and 3 indicating marked erythema involving > 50% of the palatal mucosa). Microbiological testing was undertaken to determine the number of colony forming units (CFUs) of Candida albicans.
ClO2 significantly improved the clinical appearance and microbial count (p < 0.001) after treatment, without significant side effects. Results showed marked improvement in the clinical appearance of the tissues after 10 days, with total resolution in the majority of cases. The total CFU/ml ranged from 15,000-53,000 at baseline and was reduced to < or = 500 after 10 days of treatment (p < 0.001). The mean clinical score was 2.50 at baseline, and was reduced to 0.17 after 10 days of treatment (p < 0.001).
Within the limitations of this pilot study, the effectiveness of topical chlorine dioxide (0.8%) in the management of chronic atrophic candidiasis was demonstrated. ClO2 provided a safe and clinically effective option in the management of chronic atrophic candidiasis.
评估二氧化氯（ClO₂）作为局部抗菌剂治疗老年患者慢性萎缩性念珠菌病的临床和微生物学疗效。
30例慢性萎缩性念珠菌病患者。
指导患者每天用0.8%二氧化氯漱口水（DioxiDent）漱口两次，每次1分钟，并将假牙在二氧化氯中浸泡过夜，持续10天。在基线和10天后对患者进行临床和微生物学评估，并记录任何显著的副作用。口腔软组织的临床表现按0 - 3分进行评分（0表示无临床体征，1表示腭黏膜受累小于25%，2表示腭黏膜受累25% - 50%，3表示明显红斑累及腭黏膜大于50%）。进行微生物学检测以确定白色念珠菌的菌落形成单位（CFU）数量。
治疗后二氧化氯显著改善了临床表现和微生物数量（p < 0.001），且无显著副作用。结果显示10天后组织的临床表现有显著改善，大多数病例完全消退。基线时总CFU/ml范围为15,000 - 53,000，治疗10天后降至≤500（p < 0.001）。基线时平均临床评分为2.50，治疗10天后降至0.17（p < 0.001）。
在本初步研究的局限性范围内，证明了局部使用二氧化氯（0.8%）治疗慢性萎缩性念珠菌病的有效性。二氧化氯为慢性萎缩性念珠菌病的管理提供了一种安全且临床有效的选择。
