Klein Laura Cousino, Corwin Elizabeth J, Ceballos Rachel M
Department of Biobehavioral Health, The Pennsylvania State University, 315 East Health and Human Development Building, University Park, PA 16802, USA.
Addict Behav. 2004 Jul;29(5):921-7. doi: 10.1016/j.addbeh.2004.02.023.
Leptin is a hormone involved in body weight and hunger regulation, and may contribute to the inverse relationship between cigarette smoking and body weight. Leptin levels, body mass indices (BMIs), and hunger ratings were determined in 22 nonsmokers (12 male, 10 female) and 19 cigarette smokers (11 male, 8 female). Smokers were tested after ad lib smoking and following a 24-h smoking abstinence period; nonsmokers came to the laboratory once. Leptin levels were not different among the groups. Hunger ratings, however, were higher after smoking abstinence compared to after ad lib smoking and nonsmokers (Ps<.05); levels of hunger did not differ between ad lib smokers and nonsmokers. Men reported higher hunger levels than did women, but women had higher serum leptin levels than did men, regardless of smoking condition (P<.05). Leptin levels were correlated with BMI (P<.05) among smokers only. This first study on leptin responses in female smokers suggests that leptin levels do not change following a 24-h smoking abstinence period and that leptin may not contribute to increased hunger following smoking abstinence.
瘦素是一种参与体重和饥饿调节的激素，可能与吸烟和体重之间的负相关关系有关。对22名不吸烟者（12名男性，10名女性）和19名吸烟者（11名男性，8名女性）测定了瘦素水平、体重指数（BMI）和饥饿评分。吸烟者在随意吸烟后以及经过24小时戒烟期后进行测试；不吸烟者只到实验室一次。各组之间的瘦素水平没有差异。然而，与随意吸烟后和不吸烟者相比，戒烟后的饥饿评分更高（P<0.05）；随意吸烟者和不吸烟者之间的饥饿程度没有差异。男性报告的饥饿水平高于女性，但无论吸烟状况如何，女性的血清瘦素水平高于男性（P<0.05）。仅在吸烟者中，瘦素水平与BMI相关（P<0.05）。这项关于女性吸烟者瘦素反应的首次研究表明，在24小时戒烟期后瘦素水平没有变化，并且瘦素可能不会导致戒烟后饥饿感增加。
